Croatia · Mark Nguyen, PharmD, BCEMP
- Health & Fitness
- Medicine
Welcome to PHARMWYZE, your go-to destination for engaging clinical pharmacotherapy content! Whether you're a seasoned medical professional or just starting your journey in medicine, this podcast is tailored to cater to all medicine learners. Join us for the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast, where we delve into evidence-based medicine and pharmacotherapy topics specifically curated for emergency medicine and critical care learners. Tune in now and stay ahead of the curve with PHARMWYZE!Website: www.pharmwyze.com | Social Media Accounts: linktr.ee/pharmwyze
Episodes
Syphilis: The Silent Infection? Comeback SZN? | Infectious Disease | #CodeBlueDebrief18 Mar· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast- Listen later
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📢 207,255 cases of syphilis in the United States in 2022; that is an 80% increase since 2018 per the Centers for Disease Control and Prevention (CDC). 1.6 million cases of chlamydia, 650 reports of gonorrohea, and to add to those syphilis numbers, 3800 cases of syphilis among newborns. What are we doing? Really, we've got to do better in removing the stigma behind STIs and make treatment more accessible. Website: www.pharmwyze.comShop: www.pharmwyze.com/shopSocial Links: https://links.pharmwyze.comDrugQueryInbox Request: https://pharmwyze.hopp.to/drugqueryinboxStreaming Platforms: https://pharmwyze.hopp.to/podstreamsPatreon: https://patreon.com/PHARMWYZEPaypal Donation: https://pharmwyze.hopp.to/paypaldonatePHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/sitrepnewsletterHarris, E. JAMA. 2023 May 16;329(19):1633.Tuddenham S, Hamill MM, Ghanem KG. JAMA. 2022 Jan 11;327(2):161-172.Korkowsi KA, Bachmann LH, Chan PA, et al. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.sForrestel AK, Kovarik CL, Katz KA. J Am Acad Dermatol. 2020 Jan;82(1):17-28. CDC Linkshttps://www.cdc.gov/std/syphilis/default.htmhttps://www.cdc.gov/tuskegee/timeline.htm#printNot medical advice. Educational purposes only. No relationships to report.#medicalschool #clinicalpearls #nursingschool #pharmacyschool #medicaleducation #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #medshed #foamed #emrx #pharmacology #pharmaco*kinetics #cardiology #antibiotics #neurology #patientcase #clinicalmedicine #clinicalpharmacy
- Thrombolytic Stroke BP Targets? Nitroglycerin with Inferior MI? TNK for PE? | Q&A | DrugQueryInbox15 Mar· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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🌟 Drug Query Inbox Episode 4- Patient Case Post Recap- Role of clindamycin for necrotizing fasciitis?- Changing anticonvulsant therapy?- Benefit of tenecteplase over alteplase for massive PE?Welcome to PHARMWYZE! Clinical pharmacotherapy content made for learners of all medicine backgrounds. Thanks for joining my video series, #DRUGQUERYINBOX. I often get questions in the comments on my social media platforms, which I'll compile into weekly to biweekly videos.Website: www.pharmwyze.comShop: www.pharmwyze.com/shopSocial Links: https://links.pharmwyze.comDrugQueryInbox Request: https://pharmwyze.hopp.to/drugqueryinboxStreaming Platforms: https://pharmwyze.hopp.to/podstreamsPatreon: https://patreon.com/PHARMWYZEPaypal Donation: https://pharmwyze.hopp.to/paypaldonatePHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/sitrepnewsletterReferencesPowers WJ, Rabinstein AA, Ackerson T, et al. Stroke. 2019 Dec;50(12):e344-e418. Korkowsi KA, Bachmann LH, Chan PA, et al. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.Pantel P, Peterson CD. Ann Emerg Med. 1980 Nov;9(11):588-90.Javaudin F, Lascarrou JP, Bastard QL, et al. Chest. 2019 Dec;156(6):1167-1175.Batchelor R, Liu DH, Bloom J, et al. Catheter Cardiovasc Interv. 2020 Jul;96(1):76-88.Bosson N, Isakson B, Morgan JA, et al. Prehosp Emerg Care. 2019 Sep-Oct;23(5):603-611.Not medical advice. Educational purposes only. No relationships to report. #medicalschool #clinicalpearls #nursingschool #pharmacyschool #medicaleducation #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #medshed #foamed #emrx #pharmacology #pharmaco*kinetics #cardiology #antibiotics #neurology #patientcase #clinicalmedicine #clinicalpharmacy
Missing episodes?
- Septic & Anaphylactic Shock? EtOH Withdrawal & Phenobarbital? | Acyclovir Prophylaxis? | Q&A | DrugQueryInbox v326 Feb· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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For this episode, we did something different than prior videos. There was a request from viewers on Instagram for a week of MEDIGRAM patient cases, so I've made a review of those post. Also, I included viewer questions that came from the comments! Website: www.pharmwyze.comShop: www.pharmwyze.com/shopSocial Media: linktr.ee/pharmwyzePatreon: https://patreon.com/PHARMWYZEShopify: wearfarmd.myshopify.comEtsy: https://pharmwyze.etsy.comPHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/sitrepnewsletterReferencesEvans L, Rhodes A, Alhazzani W, et al. Intensive Care Med. 2021 Nov;47(11):1181-1247. Umar Z, Ul Rasool MH, Muhammad S, et al. Cureus. 2023 Jan 12;15(1):e33695. Heindenreich PA, Bozjurt B, Aguilar D, et al. Circulation. 2022 May 3;145(18):e895-e1032. Shaker MS, Wallace DV, Golden DB, et al. J Allergy Clin Immunol. 2020 Apr;145(4):1082-1123. Hoy SM. Drugs. 2018 Oct;78(15):1605-1613.Panchal AR, Bartos JA, Cabanas JG, et al. Circulation. 2020 Oct 20;142(16_suppl_2):S366-S468. Not medical advice. Educational purposes only. No relationships to report.
- Grading Open Fractures & Prophylactic Antibiotics? | Infectious Disease | #CodeBlueDebrief1 Feb· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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🦴 Where does ceftriaxone fit in that arsenal of bug juice for that bone sticking out? How do we classify and grade open fractures? Why do guidelines recommend cefazolin and gentamicin for extensive injuries?Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. We discuss emergency medicine and critical care pharmacology and disease state management. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.Website: www.pharmwyze.comShop: www.pharmwyze.com/shopPatreon: https://patreon.com/PHARMWYZEPaypal Donation: https://www.paypal.com/donate/?hosted_button_id=PTNLSD4G5X6BASocial Media: linktr.ee/pharmwyzePHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletterAtlasVPN: http://tinyurl.com/8tahadc7Not medical advice. Educational purposes only. No relationships to report. ReferencesHoff WS, Bonadies JA, Cachecho R, Dorlac WC. J Trauma. 2011 Mar;70(3):751-4.Rodriguez L, Jung HS, Goulet JA, et al. J Trauma Acute Care Surg. 2014 Sep;77(3).Vasenius J, Tulikoura I, Vainionpaa S, Rokkanen P. Ann Chir Gynaecol. 1998;87(3):224-8.Bankhead-Kendall B, Gutierrez T, Murry J, et al. Eur J Trauma Emerg Surg. 2019 Feb;45(1):125-129. #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #thelab #medshed #foamed #emrx #pharmacology #pharmaco*kinetics #pharmacodynamics #cardiology #neurology #infectiousdisease #mechanism #mechanismofaction #moa #drugs #ketamine #propofol #etomidate #fentanyl #rxshorts #massivetransfusion #ems #emergency #antibiotics #metabolism #antipsychotics #drugs
- Seizure Prophylaxis for Traumatic Brain Injuries? | Neurology | #CodeBlueDebrief29 Jan· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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Up to 53% of patients will develop chronic epilepsy even with seizure prophylaxis in the setting of traumatic brain injuries. How do TBIs even cause seizures? When should we give seizure prophylaxis for TBIs? What anticonvulsants are considered for this indication?Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. We discuss emergency medicine and critical care pharmacology and disease state management. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.Website: www.pharmwyze.comShop: www.pharmwyze.com/shopPatreon: https://patreon.com/PHARMWYZEPaypal Donation: https://www.paypal.com/donate/?hosted_button_id=PTNLSD4G5X6BASocial Media: linktr.ee/pharmwyzePHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletterAtlasVPN: http://tinyurl.com/8tahadc7Not medical advice. Educational purposes only. No relationships to report. ReferencesOhman K, Kram B, Schultheis J et al. Neurocrit Care. 2023 Apr;38(2):345-355. Carney et al. Neurosurgery. 2017 Jan 1;80(1):6-15.Lucke-Wold et al. Seizure. 2015 Dec;33:13-23.DJohn J, Ibrahim R, Patel P, et al. Cureus. 2020 Jul; 12(7): e9117.#pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #thelab #medshed #foamed #emrx #pharmacology #pharmaco*kinetics #cardiology #neurology #infectiousdisease #mechanism #mechanismofaction #moa #drugs #ketamine #propofol #etomidate #fentanyl #calcium #mtp #massivetransfusion #ems #emergency #antibiotics #metabolism #antipsychotics #drugs
- Chlamydia & Gonorrhea 2021 Antibiotic Update? | Infectious Disease | #CodeBlueDebrief29 Jan· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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Having a burning sensation down there after a weekend of high-risky behavior? Which antibiotics are used for chlamydia and gonorrhea? What options are available for pregnant women or true allergies for these sexually transmitted diseases?Chlamydia and Gonorrhea are the two most common sexually transmitted infections in the United States. There was a fairly recent update to the CDC STI Guidelines, tune in as we'll discuss the preferred agents. Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. We discuss emergency medicine and critical care pharmacology and disease state management. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.Website: www.pharmwyze.comShop: www.pharmwyze.com/shopPatreon: https://patreon.com/PHARMWYZEPaypal Donation: https://www.paypal.com/donate/?hosted_button_id=PTNLSD4G5X6BASocial Media: linktr.ee/pharmwyzePHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletterAtlasVPN: http://tinyurl.com/8tahadc7Not medical advice. Educational purposes only. No relationships to report. ReferencesDukers-Muijrers N., Wolffs P.F.G., De Vries H., et. al.: Treatment Effectiveness of Azithromycin and Doxycycline in Uncomplicated Rectal and vagin*l Chlamydia trachomatis Infections in Women: A Multicenter Observational Study (FemCure). Clin Infect Dis 2019; 69: pp. 1946-1954.Dombrowski J.C., Wierzbicki M.R., Newman L.M., et. al.: Doxycycline Versus Azithromycin for the Treatment of Rectal Chlamydia in Men Who Have Sex With Men: A Randomized Controlled Trial. Clin Infect Dis 2021; 73: pp. 824-831.Dutra K, Lazenby G. An Update on Gonorrhea and Chlamydia. Obstet Gynecol Clin North Am. 2023 Jun;50(2):299-310.Workowski KA, Bachmann LH, Chan PA, et al. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.#pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #thelab #medshed #foamed #emrx #pharmacology #pharmaco*kinetics #cardiology #neurology #infectiousdisease #mechanism #mechanismofaction #moa #drugs #ketamine #propofol #etomidate #fentanyl #calcium #mtp #massivetransfusion #ems #emergency #antibiotics #metabolism #antipsychotics #drugs
- Hypocalcemia, Lethal Triad, and MTP? | Resuscitation | #CodeBlueDebrief29 Jan· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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Make sure to reel and deal those calcium salts during Massive Transfusion Protocol (MTP). Calcium salts are arguably the most important pharmacologic agent during MTP. Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. We discuss emergency medicine and critical care pharmacology and disease state management. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.Website: www.pharmwyze.comShop: www.pharmwyze.com/shopPatreon: https://patreon.com/PHARMWYZEPaypal Donation: https://www.paypal.com/donate/?hosted_button_id=PTNLSD4G5X6BASocial Media: linktr.ee/pharmwyzePHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletterNot medical advice. Educational purposes only. No relationships to report. ReferencesMeneses E, Boneva D, McKenney M, Elkbuli A. Massive transfusion protocol in adult trauma population. Am J Emerg Med. 2020 Dec;38(12):2661-2666. Wray JP, Bridwell RE, Schauer SG, Schakelford SA et al. The diamond of death: Hypocalcemia in trauma and resuscitation. Am J Emerg Med. 2021 Mar:41:104-109. Helsoot D, Fitzgerald M, Lefering R et al. Trauma-induced disturbances in ionized calcium levels correlate parabolically with coagulopathy, transfusion, and mortality: a multicentre cohort analysis from the TraumaRegister DGU®.Crit Care. 2023 Jul 6;27(1):267. Vasudeva M, Mathew JK, Groombridge C et al. Hypocalcemia in trauma patients: A systematic review. J Trauma Acute Care Surg. 2021 Feb; 90(2): 396–402.Robinson A, Rech MA, DeChristopher PJ et al. Defining the optimal calcium repletion dosing in patients requiring activation of massive transfusion protocol. Am J Emerg Med. 2023 Aug:70:96-100. Borowko R, Vignon PO, Lutz N. et al. The lethal triad of hemorrhage. Rev Infirm. 2021 Aug-Sep;70(273):16-18.#pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #thelab #medshed #foamed #emrx #pharmacology #pharmaco*kinetics #cardiology #neurology #infectiousdisease #mechanism #mechanismofaction #moa #drugs #ketamine #propofol #etomidate #fentanyl #calcium #mtp #massivetransfusion #ems #emergency #antibiotics #metabolism
- Physostigmine for Anticholinergic Toxicity? | Toxicology | #CodeBlueDebrief20 Nov 2023· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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👾 Physostigmine is a reversal agent for anticholinergic toxicities. By inhibiting acetylcholinesterase, increased acetylcholine becomes available at the synapses. It is an excellent drug to reverse antimuscurinic poisonings. Unfortuanetely, it has a negative stigma from prior case reports associated with TCA deaths. The Akorn manufacturer went bankrupt recently, leaving the US without product available for the market. Recently, the FDA announced they would allow temporary importation from a company in Germany. Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. Make sure to hit the follow, subscribe, and notification bell as we get into the episode's topic. For this episode, we'll be discussing anticholinergic toxicity and the use of physostigmine. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.Website: www.pharmwyze.comSocial Media: linktr.ee/pharmwyzePHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletterShop: www.pharmwyze.com/shopReferencesNewton RW. JAMA . 1975 Mar 3;231(9):941-3.Pentel P, Peterson CD. Ann Emerg Med . 1980 Nov;9(11):588-90. Wang GS et al. Clin Toxicol (Phila). 2021 Aug;59(8):698-704.Watkins JW et al. J Med Toxicol. 2015 Jun;11(2):179-84. Fratta KA, Ginder M, Haggerty DA. The Journal of Emergency Medicine, Vol. 65, No. 4, pp. e366–e368, 2023McCoy CE, Honda R. J Educ Teach Emerg Med. 2023 Jan 31;8(1):S25-S47. Elkhazeen A et al. J Forensic Sci . 2023 Jan;68(1):339-342. Nishtala PS, Salahudeen SJ, Hilmer SN. Expert Opin Drug Saf . 2016 Jun;15(6):753-68. https://www.fda.gov/drugs/drug-shortages/october-31-2023-temporary-importation-available-physostigmine-injectionhttps://www.ashp.org/drug-shortages/current-shortages/drug-shortage-detail.aspx?id=721&loginreturnUrl=SSOCheckOnly
- Ketamine vs Etomidate for Unstable Patients? | Rapid Sequence Intubation | #CodeBlueDebrief20 Nov 2023· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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Induction agents are an essential component of rapid sequence intubation. They work synergistically with neuromuscular blockers. As the paralytics relax the vocal cords for optimal conditions as the endotracheal tubes is being passed, induction agents provide amnesia and make the patient unconscious. That is an important thing to mention. How much drug does the patient really need when they're body is barely hanging on? There is such a thing as drug toxicities and we want to keep it safe. Let's briefly review these two agents. Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. Make sure to hit the follow, subscribe, and notification bell as we get into the episode's topic. We'll be discussing ketamine and etomidate for hemodynamically unstable patients for rapid sequence intubation?
Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.
- Max Vasopressors? ASA STEMI Dosing? Early High Dose Statins? K-hole Content? | Q&A | DrugQueryInbox v110 Nov 2023· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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#DQI (DRUGQUERYINBOX) V1- Is there a max dose to vasopressors?- What are my thoughts on ASA STEMI dosing? What if patient is on OAC and daily baby ASA?- Why do we give statins in the acute setting?- Is PHARMWYZE in the K-hole making his content?Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.If you want to support the work that I do, stop by my donate page pharmwyze.com/donate or drop by the shop, pharmwyze.com/shop.
- Pharmacologic Agents for Acute Variceal Bleeds? | Liver Disorders | #CodeBlueDebrief10 Nov 2023· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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During my time as a COVID resident, I had an invaluable experience taking care of severely sick COVID and decompensated cirrhotic patients. Both patient populations are complex, requiring consistent, thorough patient workup. Acute variceal bleeds are a severe complication of cirrhosis. This can lead to hemmorhagic shock. Let's discuss medication used for acute variceal bleeds.
Welcome to PHARMWYZE! Clinical pharmacotherapy content made for learners of all medicine backgrounds. Thanks for joining me on the Code Blue Debrief YouTube & Podcast series. The focus will be evidence-based medicine and pharmacotherapy topics for emergency medicine and critical care learners. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.
- Thrombolytics in recurrent stroke? Chlamydia treatments? Lipophilic BB? HSV encephalitis? | Q&A | DrugQueryInbox v210 Nov 2023· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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#DQI (DRUGQUERYINBOX) V2- Systemic thrombolytics for recurrent ischemic stroke?- Chlamydia treatment regimens?- Lipophilic vs hydrophilic beta blockers?- Herpes encephalitis?Welcome to PHARMWYZE! Clinical pharmacotherapy content made for learners of all medicine backgrounds. Thanks for joining my video series, #DRUGQUERYINBOX. I often get questions in the comments on my social media platforms, which I'll compile into weekly to biweekly videos.Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.If you want to support the work that I do, stop by my donate page pharmwyze.com/donate or drop by the shop, pharmwyze.com/shop.
- Underdosing Initial Benzodiazepines for Seizures? | Status Epilepticus | #CodeBlueDebrief17 Oct 2023· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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Acutely terminating seizures often puts us in a dilemma; too little and underdose, or too much and toxicities. Working along this spectrum requires a general understanding of the guidelines recommendations. It'll also be good for you to understand benzodiazepine pharmaco*kinetics. Let's review initial benzodiazepine dosing in the treatment of status epilepticus (SE)!Welcome to PHARMWYZE! Clinical pharmacotherapy content made for learners of all medicine backgrounds. Thanks for joining me on the Code Blue Debrief YouTube & Podcast series. The focus will be evidence-based medicine and pharmacotherapy topics for emergency medicine and critical care learners. I've shifted content development into longer formats and would love to hear your input! Please let me know your thoughts in the comments below.Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts.If you want to support the work that I do, stop by my donate page pharmwyze.com/donate or drop by the shop, pharmwyze.com/shop.ReferencesLee, S. Diagnosis and Treatment of Status Epilepticus. J Epilepsy Res. 2020 Dec 31;10(2):45-54.Kapur et al. Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. N Engl J Med. 2019 Nov 28;381(22):2103-2113.Kohl et al. Status epilepticus and benzodiazepine treatment: Use, underdosing and outcome - insights from a retrospective, multicentre registry. Seizure. 2023 Apr;107:114-120. doi: 10.1016/j.seizure.2023.03.020.Silbergleit et al. RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. Epilepsia . 2011 Oct;52 Suppl 8(Suppl 8):45-7.Sathe et al. Underdosing of Benzodiazepines in Patients With Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial. Acad Emerg Med . 2019 Aug;26(8):940-943.
Glauser et al. Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee ofthe American Epilepsy Society. Epilepsy Curr. 2016 Jan-Feb; 16(1): 48–61.Leppik IE et al. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA 1983;249:1452–1454.Alldredge BK et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 2001;345:631–637.
- Modify "LOAD" Pretreatment? | Rapid Sequence Intubation | #CodeBlueDebrief6 Oct 2023· The Code Blue Debrief Podcast: A Clinical Pharmacotherapy YouTube & Podcast
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The original use of LOAD has fallen out practice for severe TBIs, but yet, the acronym is still discussed/taught as a part of pretreatment. Out of lidocaine, opioids, atropine, and defasciculation dosing, opioids are the only intervention with consistent data on neuroprotective properties in the setting of RSI and TBI. I have modified the acronym "LOAD" to lidocaine, opioids, access, and down or delay. Consider these questions for each: Is this an indication for topical or nebulized lidocaine for an awake intubation?
Does the patient need opioids for pain control or neuroprotection? What access do I have to get the medications into the patient? Does the patient need agents for vasoactive support or delayed sequence intubation? Going through each component allows me to anticipate complications from anticipated airways.
Consider applying it to your practice if you find value in going through pretreatment LOAD this way.
Welcome to PHARMWYZE! Clinical pharmacotherapy content made for learners of all medicine backgrounds. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast series. The focus will be evidence-based medicine and pharmacotherapy topics for emergency medicine and critical care learners.
Social Media Accounts: linktr.ee/pharmwyze#RXSHORTS: https://www.youtube.com/@PHARMWYZE/shorts#MEDIGRAM: www.pharmwyze.com/medigramWebsite: www.pharmwyze.com
